#Chromium deficiency symptoms in humans skin
Ingestion of large amounts of chromium (VI) can lead to severe respiratory, cardiovascular, gastrointestinal, hepatic and renal damage and potentially deathĬhromium (VI) may cause occupational asthma in sensitised individualsĬhronic inhalation of chromium (III) salts causes a range of inflammatory changes in the respiratory tractĬhronic inhalation of high levels of chromium (VI) (in poorly controlled occupational settings) may cause nasal septum ulceration and perforation, respiratory irritation, lung cancer and possible renal effectsĭermal contact in chromium-sensitised individuals can lead to allergic dermatitis and chronic dermal exposure can result in deeply penetrating skin ulcers if left untreatedĬhromium (VI) compounds have mutagenic potentialĬhromium (VI) compounds are carcinogenic to humans but chromium (III) compounds are not classifiable as to their carcinogenicity to humans The respiratory tract is the primary target organ for inhaled chromium Insoluble inhaled chromium particles can remain in the lung for a long timeĪbsorbed chromium is distributed to all tissues of the body.Ĭhromium (VI) is unstable in the body, and is rapidly reduced to chromium (V), chromium (IV) and ultimately to stable chromium (III) by endogenous reducing agentsĪbsorbed chromium is excreted primarily in the urine and to a lesser extent in faeces
Uptake of chromium depends on the valency (III or VI) and solubility of the chromium-containing compoundĪbout 0.5% to 1% of chromium (III) present in the normal diet is adsorbed by the gastrointestinal tract, while chromium (VI) is more readily absorbed by both inhalation and oral routes
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